Objective: To discuss the protective effect of the combination of traditional Chinese and Western medicine in treating early-stage kidney damage aroused by hypertension

and to investigate its influence on inflammation and coagulation-fibrinolysis system. Method: Ninety-five patients were randomly divided into the control group (47 cases) and the combination group with traditional Chinese and Western medicine treatment (48 cases) by a random number table. Patients in the control group received 10 mg enalapril tablets and 10 mg amlodipine once daily. Based on the treatment of the control group

patients in the combination group added 6 g Liuwei Dihuang Wan thrice daily and 10 mL Huangqi Sanqi oral liquids twice daily. All patients in two groups received 12 weeks of treatment. Before and after treatment

24-h microalbuminuria (mAlb)

ratio of microalbuminuria and creatinine (ACR)

cystatin C (CysC)

β2-microglobulin (β2-MG)

urinary N-acetyl-β-D-glucosaminidase (NAG)

interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

plasmic D-dimer (D-D)

fibrinogen (FIB)

urea nitrogen (BUN) and creatinine (CR) were detected. Scores of liver-kidney yin deficiency combined with blood stasis were graded. Result: The blood-pressure control and the curative effect of Chinese medical symptom in the combination group were superior to those in the control group (P<0.05). After treatment

levels of mAlb and ACR in the combination group were lower than those in the control group (P<0.01). But the changes of levels of BUN and Cr were not obvious

and they were within normal limits. Levels of CysC

β2-MG

NAG

D-D

FIB

IL-6 and TNF-α were lower than those in the control group (P<0.01). Conclusion: The effect of Liuwei Dihuang wan and Huangqi Sanqi oral liquid combined routine Western medicine therapy is superior to using Western medicine treatment alone. Its mechanism of action may be related to reducing the inflammatory response and regulating coagulation-fibrinolysis system.