Objective: To explore the chronic toxicity of Gansui Banxia Tang (GBT) on heart and kidney of rats. Method: Eighty healthy SD rats were randomly divided into four groups:the normal group

the high-

middle-

and low-dose GBT groups (37

18.5

9.25 g·kg-1). The corresponding medicines at 0.02 mL·g-1were intragastrically administrated to rats for 90 days. After the last dose

the blood samples of the half rats from each group were collected. The heart function indexes including creatine phosphate kinase (CK)

lactic dehydrogenase (LDH) and α-hydroxybutyric dehydrogenase (α-HBDH)

and the kidney function indexes including blood urea (UREA)

serum creatinine (CREA) and uric acid (UA) were detected. The morphology and histology of the heart and kidney were observed by HE staining. The remaining rats in each group were observed continuously for two weeks

and the above indexes were detected again. Result: In medicine taking and during following observation

there were no significant differences for the relative function indexes and the change of morphology in heart and renal between any two groups. Conclusion: GBT has no remarkable effects on heart and renal function

and morphology of rats by long-term medication.