Objective: To explore the chronic toxicity of Gansui Banxia Tang (GBT) on blood routine

blood glucose (GLU) and thyroid morphology of rats. Method: Eighty healthy SD rats were randomly divided into four groups:the normal group

the high-

middle-

and low-dose GBT groups (37

18.5

9.25 g·kg-1). The corresponding medicines at 0.02 mL·g-1were intragastrically administrated to rats for 90 days. After the last dose

the blood samples of the half rats from each group were collected. The blood routine indexes including red blood cell (RBC)

white blood cell (WBC)

hemoglobin (HGB)

platelet (PLT) and GLU were detected. The morphology and histology of the thyroid were observed by HE staining. The remaining rats in each group were observed continuously for two weeks

and the above indexes were detected again. Result: In medicine taking

compared with the control group

the number of WBC significantly increased in high-dose GBT group (P<0.05)

the number of WBC had no significant changes in the middle-and low-dose GBT groups

the number of RBC

HGB and PLT had no significant changes in all dose GBT groups. While in medicine taking and during the following observation

GLU showed no significant changes in all dose GBT groups. No obvious change for morphology of the thyroid was observed. Conclusion: GBT could increase the number of white blood cell reversibility by long-term

medication. But there were no effects on the number of RBC

HGB

PLT

GLU and thyroid morphology of rats.