Objective: The aim of this study was to compare the effect between Western medicine treatment combined with treatment of traditional Chinese medicine(Yiqi Yangxue Huoxue Fang) and western medicine alone in patients with refractory idiopathic thrombocytopenic purpura(rITP). Method: In this study

35 rITP patients were divided into two groups which were treated with Western medicine combined with traditional Chinese medicine and western medicine alone

respectively. The curative effects were evaluated after 6 months. Result: Both total effective rate and complete reaction rate of rITP patients treated with combination of traditional Chinese medicine and western medicine were much higher than those treated with Western medicine alone. After treatment

platelet count(PLT) and plateletcrit(PCT) were much higher and mean platelet volume(MPV) and platelet distribution width(PDW) were much lower (P < 0.01) in the combination treatment group than those in western medicine alone treatment group. Platelet associated IgG(PAIgG) increased much higher in combination treatment group than those in western medicine alone treatment group

and so were the platelet-producing megakaryocytes in bone marrow smear. Conclusion: The combination treatment of traditional Chinese medicine (Yiqi Yangxue Huoxue Fang) with western medicine had a good curative effect in rITP patients.