Objective: This study was conducted to observe the clinical efficacy of Bushen Huoxue decoction on patients with chronic heart failure(CHF)

and its effect on immuno-inflammatory response. Method: In this study

sixty patients were divided into two groups by random number table

with 30 cases in the control group by routine western medicine treatment

while 30 cases in the treatment group treated by the combination of western conventional therapy with Bushen Huoxue decoction

taking a dose once for 14 days. We observed the changes of clinical symptom integrals

left ventricular end diastolic diameter(LVED)

left ventricular ejection fraction (LVEF)

brain natriuretic peptide (BNP)

tumor necrosis factor α(TNF-α)

interleukin-6(IL-6) and pentraxin-3(PTX-3) in the two groups. Result: The total effective rate of clinical symptom integrals in the treatment group (90%) was improved better than the control group (80%)(P<0.05). The level of [BNP(1 058.72±575.62) ng·L-1

IL-6(6.88±0.91) ng·L-1

TNF-α(251.54±52.72) ng·L-1

PTX-3(3.16±0.60) μg·L-1] in treatment group after treatment were improved significantly than the control group[(1 542.26±732.18) ng·L-1

(9.63±1.25) ng·L-1

(283.24±48.58) ng·L-1

(3.40±0.56) μg·L-1] (P<0.05).The improvements in LVED and LVEF in the both groups were better than those before the treatment

but the difference was not statistically significant. Conclusion: Bushen Huoxue decoction could obviously improve the CHF patient's cardiac function

reduce the contents of TNF-α

IL-6

BNP and PTX-3

restrain immuno-inflammatory response and improve prognosis.