Objective: To observe the curative efficacy of Zhizhu Kuanzhong capsules combined rabeprazole sodium enteric-coated tablets in treating gastroesophageal reflux disease (GERD)

and to investigate its influence on patients' quality of life. Method: One hundred patients with GERD were randomly divided into the control group (50 cases) and the observation group (50 cases) by a random number table. Patients in both two groups received 20 mg rabeprazole sodium enteric-coated tablets in the morning and evening. Patients in the control group added 5 mg mosapride citrate tablets thrice daily. Patients in the observation group added 3 Zhizhu Kuanzhong capsules thrice daily. All patients in two groups received 8 weeks of treatment. Before and after treatment

scores of GERD questionnaire (GERDQ)

health inventory of SF-36 and deficiency of spleen and stagnation of Qi were graded. Result: After therapy

the curative effect of inflammation and Chinese medical syndrome in the observation group were superior to those in the control group (P<0.05). Eight dimensions scores including SF-36 scale physiological function

physiological function

body pain

general health

life energy

mental health

social function and emotional function in the observation group were better than those in the control group (P<0.05). Besides

scores of GERDQ and spleen deficiency and Qi stagnation syndrome in the observation group were inferior to those in the control group (P<0.05). Conclusion: Zhizhu Kuanzhong capsules jointed rabeprazole could reduce the clinical symptoms and signs

enhance the life quality of GERD patients. Its clinical curative effect is superior to using Western medicine treatment alone.