Objective: To observe the curative efficacy and the mechanism of Ziren Zhixue decoction combined omeprazole in treating peptic ulcer bleeding (PUB). Method: Ninety patients with PUB were randomly divided into the control group (45 cases) and the combination group with traditional Chinese and Western medicine treatment (45 cases) by a random number table. Patients in the control group received 40 mg omeprazole injections by intravenous infusion once daily. Based on the treatment of the control group

patients in the combination group added Ziren Zhixue decoction. All patients in both two groups received 7 days of treatment. Hemostatic time and hospital stay were recorded. Before and after treatment

scores of the main symptoms and signs were graded. Levels of platelet α-granule membrane protein-140 (GMP-140)

thromboxane B2(TXB2) and 6-ketone prostaglandin F1α(6-Keto-PGF1α) were detected. Result: The curative effects rate in the combination group was superior to that in the control group (P<0.05). Besides

hemostatic time and hospital stay of the combination group were shorter than those of the control group (P<0.01). The symptoms including melena

epigastric pain

lassitude

dizziness

palpitation

color of face

and the score of clinical signs in the combination group were inferior to those in the control group (P<0.01). After treatment

TXB2 level increased

6-Keto-PGF1αlevel decreased in two groups (P<0.01). GMP-140 change in the control group was not obvious

while the GMP-140 increased in the combination group compared before the treatment (P<0.01). GMP-140 and TXB2 levels in the combination group were higher than those in the control group

while 6-Keto-PGF1α level was lower than that in the control group (P<0.01). Conclusion: Ziren Zhixue decoction combined omeprazole could reduce hemostatic time and hospital stay

improve clinical symptoms in treating patients with PUB. Its clinical curative effect is superior to using Western medicine treatment alone.