As a traditional Chinese herbal medicine

Stigma Maydis contain a variety of active ingredients

including flavonoids

which have many important physiological activities. This paper systematically summarized the researches from domestic and abroad in the recent 35 years

to review the composition and pharmacological effects of flavonoids in Stigma Maydis

which can serve as a theoretical basis for its medicinal value. With the advances of equipments and technology

flavonoids of Stigma Maydisto gained more and more attention of scientists

the present review gives the details about the structureof flavone derivatives from Stigma Maydis in the domestic and abroad.Currently

there are 29 compounds isolated from Stigma Maydis

including flavonoids(luteolin

apigenin)

flavonols (isorhamnetin)

isoflavones(formononetin)

flavonoid glycosides. As an active compound

the Stigma Maydis flavonoids have been found to have several pharmacological effects

such as

anti-hyperlipidemic effects

hyperglycemia reduction anti-diabetic

anti-cardiovascular

antioxidant

antitumor

antibacterial

and anti-fatigue activity. But in general

the flavonoids studied were mainly natural. It was still unclear about the pharmacological activities and mechanism of different monomer compounds. In addition

studies on pharmacological effects were just in vitro

further validation in clinical trials were required.