Objective: To establish a method for determining dissolution of baicalin in Xiao'er Qingfei dispersible tablets and to provide a reference for quality control of this preparation. Method: HPLC was employed to determine the content of baicalin with mobile phase of methanol-water-phosphate (47:53:0.2) and detection wavelength of 280 nm.Taking dissolution of baicalin at the same time as index

single factor tests were adopted to investigate rotation rate

dissolution medium and method

difference of dissolution between Xiao'er Qingfei dispersible tablets and Xiao'er Qingfei tablets. Result: Baicalin had a good linear relationship in the range of 0.025-0.125 g·L-1 with r of 0.999 9 and average recovery of 100.41%.The paddle was adopted to determine dissolution of Xiao'er Qingfei dispersible tablets with pH 6.8 phosphate buffer as dissolution medium

rotation rate of 75 r·min-1 and sampling time of 40 min.Cumulative dissolution of Xiao'er Qingfei dispersible tablets was more than 70% in 15 min

while it was 40% for ordinary tablets. Conclusion: This method is reliable

reproducible and suitable for dissolution determination of baicalin in Xiao'er Qingfei dispersible tablets.