Objective: To observe the effect of Qiwei Baizhu San and its extract on the expressions of interferon-α (IFN-α)

interleukin-4 (IL-4) and interleukin-10 (IL-10) in the small intestinal epithelial cell of enteric dysfunctions in mice. Method: The enteric dysfunctions model was induced in ICR mice by intragastric administration of ceftriaxone sodium

lincomycin and folium sennae decoction. The stool

diarrhea and fecal bacterial were observed. The mice were randomly divided into four groups:the model group (MG)

the Qiwei Baizhu San group (QG

5.2 g·kg-1)

the Qiwei Baizhu San extract group (QTG 0.94 g·kg-1)

and the normal control group (NG).The mice in the treatment groups received 0.4 mL volume of the corresponding medicines and the mice in the MG

NG received the same volume of distilled water. The mice were sacrificed at 3

7

9

11

13 days after modeling. The positive expressions of IFN-α

IL-4 and IL-10 in small intestinal epithelial cell were observed by using immunohistochemistry assay. Result: Compared with the NG

the expression of IFN-α increased at day 3 and 7 (P <0.05)

then gradually decreased at day 9

11 13

while the results were still higher than the NG

QG and QTG (P <0.05). The levels of IL-4

IL-10 decreased in the NG

QG and QTG (P <0.05). Compared with MG

the expression of IFN-a decreased at all days (P <0.05)

the levels of IL-4

IL-10 increased at day 9 (P <0.05)

and these results had no significant difference between QG and QTG. Conclusion: Qiwei Baizhu San and its extracts could inhibit the intestinal inflammation and reduce immune injury by reducing expression of IFN-a

increasing the levels of IL-4

IL-10 in the small intestine.