Objective: To observe therapeutic effects of traditional Chinese medicine Yishen Tongluo decoction on diabetic nephropathy(DN). Method: One hundred and forty-two patients with diabetic nephropathy were randomLy divided into three Groups. 40 patients in control group were treated only by western medicine

50 patients in treatment group were treated Ginkgo-dipyridolum injection(GDI) combined with western medicines;52 patients in treatment group were treated by astragalus injection and Yishen Tongluo decoction combined with western medicines

with a treatment course of 4 weeks for three groups. The changes of the therapeutic efficacy

fasting blood glucose (FBG)

postprandial dlood glucose (PBG)

total cholesterol(TC)

triglyceride (TG)

low-density lipoprotein(LDL-L)

high-density lipoprotein (HDL-L)

24-hour urinary protein quantity

urine albumin excretion rate(UAER)

urineβ2-microgiobulin(β2-MG)

blood urine nitrogen (BUN)

serum creatinine (SCr)

creatinine clearance rate(CCr)

glycosylated hemoglobin(HbA1c)

homocysteine(Hcy)

intima-media thickness(IMT)

et al. Result: The total effective rate in treatment group A was 68.0%(34/50 cases)

and in treatment group B was 86.5%(45/52 cases)

which was obviously higher than that in control group(55.5%

22/40 cases) (P< 0.05). Between in treatment groups

deffrences are statistically significant(P< 0.05). Conclusion: GDI can decrease the amount of excretingm icroalbum inuria in diabetes. astragalus injection plus Yishen Tongluo decoction can decrease significantly the amount of excretingm icroalbum inuria and protect renal function in diabetes.