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纸质出版日期:2015
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万春霞. 益气固本汤联合穴位贴敷对儿童支气管哮喘疗效和免疫功能的影响[J]. 中国实验方剂学杂志, 2015,21(9):180-183.
WAN Chun-xia. Influence of Effect and Immune Function in Children with Bronchial Asthma After Therapy of Inhaled Corticosteroid by Therapy for Yiqi Guben Tang Combined with Acupoint Sticking[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(9): 180-183.
万春霞. 益气固本汤联合穴位贴敷对儿童支气管哮喘疗效和免疫功能的影响[J]. 中国实验方剂学杂志, 2015,21(9):180-183. DOI: 10.13422/j.cnki.syfjx.2015090180.
WAN Chun-xia. Influence of Effect and Immune Function in Children with Bronchial Asthma After Therapy of Inhaled Corticosteroid by Therapy for Yiqi Guben Tang Combined with Acupoint Sticking[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(9): 180-183. DOI: 10.13422/j.cnki.syfjx.2015090180.
目的: 观察益气固本汤联合穴位贴敷对支气管哮喘儿童吸入激素治疗疗效和免疫功能的影响. 方法: 随机将2012年10月—2014年8月收治我院的86例哮喘患儿分为两组
对照组给予吸入激素治疗
观察组在对照组的基础上
观察组给予益气固本汤联合穴位贴敷治疗
观察两组的治疗临床疗效、哮喘发作次数、感冒次数、治疗前后细胞免疫及体液免疫功能指标. 结果: ①治疗6个月后
观察组的总有效率为86.05%
对照组的总有效率为72.09%
组间差异无统计学意义.治疗12个月后
观察组的总有效率为95.35%
对照组的总有效率为81.40%
组间差异有统计学意义(P< 0.05).②治疗期间
观察组哮喘发作次数为(2.8±0.3)次
对照组哮喘发作次数为(3.1±0.4)次
组间差异具有统计学意义(P< 0.05);观察组感冒次数为(2.1±0.3)次
对照组感冒次数为(3.4±0.2)次
组间差异具有统计学意义(P< 0.05).③观察组治疗前的CD3+
CD4+
CD8+较对照组差异均不显著;治疗后
两组的CD3+
CD4+较治疗前高
CD8+较治疗前低
差异显著(P< 0.05).且观察组治疗后的CD3+
CD4+较对照组高
CD8+较对照组低
组间差异显著(P< 0.05).④观察组治疗前的IgA
IgE
IgG
IgM
胰岛素样生长因子-I(IGF-I)较对照组差异均不显著;治疗后
两组的IgA
IgG
IgM
IGF-I较治疗前高
IgE较治疗前低
差异显著(P< 0.05).且观察组治疗后的IgA
IgG
IgM
IGF-I较对照组高
IgE较对照组低
组间差异显著(P< 0.05). 结论: 益气固本汤联合穴位贴敷治疗支气管哮喘患儿的临床疗效显著
能缓解哮喘患儿的临床症状
降低支气管哮喘患儿的哮喘复发率
增强细胞免疫和体液免疫功能.
Objective: The purpose of this study was to observe the influence of effect and immune function in children with bronchial asthma after therapy of inhaled corticosteroid by treatment of Yiqi Guben Tang combined with acupoint sticking. Method: In this study
86 children with bronchial asthma from October 2012 to August 2014 were randomly divided into two groups. The control group was given therapy of inhaled corticosteroid
on the basis of control group
the observation group was given therapy of Yiqi Guben Tang combined with acupoint sticking
then clinical curative effect
the number of asthma attacks and colds
indexes of cellular immunity and humoral immunity function before and after treatment were observed. Result: After treatment of 6 months
total effective rate in observation group was 86.05%
while total effective rate in control group was 72.09%
there was no statistically significant difference between the two groups. After treatment of 12 months
total effective rate in observation group was 95.35%
total effective rate in control group was 81.40%
with no statistically significant difference between the two groups. During the treatment
asthma attack frequency in observation group was (2.8±0.3) times
that in control group was (3.1±0.4) times
there was statistically significant difference between the two groups (P <0.05);cold frequency in observation group was (2.1±0.3) times
that in control group was (3.4±0.2) times
there was statistically significant difference between the two groups (P< 0.05). Difference of CD3+
CD4+
CD8+ before treatment between the two groups had no significant difference;after treatment
CD3+ and CD4 + of both two groups were higher than before treatment
while CD8+ was lower
with significant difference (P <0.05). CD3+ and CD4+ after treatment in observation group were higher than those in control group
while CD8+ was lower
with significant difference between both groups (P <0.05). IgA
IgM
IgE
IgG and insulin-like growth factor(IGF-I) before treatment between groups had no significant difference;after treatment
IgA
IgG
IgM and IGF-I of two groups were higher than before treatment
while IgE was lower
with significant difference (P <0.05). IgA
IgG
IgM and IGF-I after treatment in observation group were higher than those in control group
while IgE was lower
with significant difference between groups (P <0.05). Conclusion: The clinical efficacy of therapy of Yiqi Guben Tang combined with acupoint sticking in the treatment of children with bronchial asthma was significant
it can alleviate clinical symptoms of asthmatic children
reduce the recurrence of asthma in children with bronchial asthma
strengthen the function of cellular immunity and humoral immunity.
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