Objective: The aim of this study was to observe and compare the curative effect of Pudilan Xiaoyan oral liquid and ribavirin in the treatment of children with hand foot and mouth disease

to obtain a better therapy. Method: In this study

two hundred and twenty cases diagnosed as hand foot and mouth disease in our hospital from 2010 May to 2013 December were selected and randomly divided into observation group and control group

with 110 patients in control group by conventional rehydration

symptomatic treatment based on the use of ribavirin treatment

and 110 cases in observation group

in the conventional treatment based on the use of Pudilan Xiaoyan oral liquid treatment. The treatment course lasted for 5 days

and the clinical treatment effects were compared between the two groups

including total efficiency

rash

bleb subsidise time

time for body temperature recovery

RV-Ag negative conversion rate and adverse circumstances etc. Result: The total effective rate of observation group was 93.3%

higher than 76.2% of the control group (P <0.05)

the observation group 3 days and 5RV-Ag negative rate were 85.8% and 92.20% in the observation group

higher than 71.30%

75.51%in the control group (P <0.05);the rash

bleb subsidise time in the observation group is (2.77±0.54) d and (2.91±0.70) d

time for body temperature recovery is (3.37±0.61) d

all were slightly lower than those of the control group (P <0.05);between the two groups

the difference in adverse reaction rate was not statistically significant. Conclusion: Pudilan Xiaoyan oral liquid and ribavirin can be used in the treatment in children with hand foot mouth disease

which can

to some extent

alleviate symptoms in children with hand foot and mouth disease

Pudilan Xiaoyan oral liquid has stronger ability to inhibit the proliferation of the virus

the symptoms subsided faster

and no obvious adverse reaction was observed. And the mechanism is related to the anti-inflammatory and antiviral synthesis effect of Pudilan Xiaoyan oral liquid. Pudilan Xiaoyan disinfection oral liquid is effective in the treatment in children with hand foot and mouth disease

and is worth of the clinical promotion.