Objective: To discuss the amelioration effect of Bushen Huoxue decoction on cognition impairment of diabetes

and to investigate its influence on oxidative stress and inflammatory response. Method: One hundred and four patients were randomly divided into the control group (57 cases) and the observation group (57 cases) by a random number table. Patients in the control group received 30 mg nimodipine tablets thrice daily and 100 mg aspirin enteric-coated tablets once dialy. Based on the treatment of the control group

patients in the observation group added Bushen Huoxue decoction. All patients in both two groups received 3 months of treatment. Before and after treatment

cognitive ability was evaluated by Montreal cognitive assessment (MoCA)

levels of fasting blood-glucose (FBG)

glycosylated hemoglobin (HbAlc)

insulin resistance index (HOMA-IR)

superoxide dismutase (SOD)

malondialdehyde (MDA)

total antioxidant capacity (T-AOC)

interleukin１β (IL-1β)

tumor necrosis factor-α (TNF-α) and homocysteine (HCY) were detected. Result: After treatment

scores of visuospatial skills

physical performance

attention

language

abstract

memory

delayed memory

disorientation and MoCA scale were higher in the observation group than those in the control group (P <0.05

P <0.01). Levels of HbA1c and HOMA-IR were lower

levels of T-AOC and SOD were higher

level of MDA was lower

levels of TNF-α

IL-1β and Hcy were lower in the observation group than those in the control group (P <0.01). Conclusion: Bushen Huoxue decoction could improve the cognitive ability of patients with type 2 diabetes mellitus. Its mechanism of action may be related to ameliorating insulin resistance

oxidative stress and inflammatory response.