Objective: To optimize processing method of Polygonati Rhizoma with wine which recorded in the 2005 edition of Guizhou Province Processing Specification of Chinese Herbal Pieces

and compare with others. Method: Taking composite score of color score

water-soluble extract

ethanol-soluble extract

contents of total polysaccharides and total saponins as index

orthogonal test was adopted to optimize processing method of Polygonati Rhizoma with wine which recorded in the 2005 edition of Guizhou Province Processing Specification of Chinese Herbal Pieces

and compared with other processing methods. Result: The best processing method was steaming 3 h

moistening 3 h

repeated 4 times.This method ranked second in these five methods.Detection values of processing products among these five methods were very significant. Conclusion: This optimized method is one of the best.Different processing methods can lead to change of chemical composition and their dissolution.