Objective: To investigate effect and mechanism of Begonia grandis sinensis through studying effective actions of two extracts on chronic pelvic inflammatory disease (CPID) rats. Method: CPID rats were separated to 7 groups and 8 rats in each group.Sham operation group only accepted surgery no modeling

while other rats were treated by mechanical damage and mixed infection and divided into the mode group

butanol high and low groups

ethyl acetate high and low groups and positive group.After treatment of administration for 14 days (sham operation group and model group only treated by water as negative control)

uterine swelling degree

uterine specimen

level of interleukin-2(IL-2) and IL-6 of all the groups were detected. Result: These two extracts of B. grandis sinensis could inhibit uterine swelling

improve degree of inflammation in the uterus

restore concentrations of IL-2 and IL-6 to normal level in CPID rats. Conclusion: B. grandis sinensis can effectively reduce uterine inflammation of rats

its mechanism is relative with inhibition of inflammatory factors.