Objective: The aim of this study was to observe the efficacy of combination of traditional Chinese medicine(TCM) periodic therapy and western medicine clomiphene and progynovain treating polycystic ovarian syndrome(PCOS) causing infertility. Method: In our study

58 patients with PCOS causing sterility were randomly divided into the control group (n=29) and the treated group (n=29).The treated group received the combination therapy and the control group was treated by the same dosage of clomiphene and progynova. Both groups received continuous treatment for 3 menstrual cycles. During treatment the endometrial thickness and type

the ovulation rate

the pregnancy rate

luteinized unruptured follicle syndrome(LUFS) rate

adverse reaction to clomiphene citrate and ovarian hyperstimulation syndrome(OHSS) rate were observed. Result: The periodic ovulation rate in the treated group was 80.28%

while in the control group it was 64.38%

with significant difference between two groups (P<0.05).The percentage of A type endometrium in the treated group was higher than that in the control group

the difference was significant (P<0.05). The total pregnancy rate is higher than that in the control group

but with no significant difference. Comparison of the occurrence of LUFS

adverse reaction to clomiphene citrate and OHSS between the two groups showed no significant difference. Conclusion: The combination therapy of clomiphene

progynova and TCM periodic therapy has a better therapeutic effect in treating PCOS causing infertility than that which only uses western medicine clomiphene and progynova.