Objective: To observe the clinical effect of modified Jianpi Xiaozhi decoction in treating diabetic gastric paralyze (DGP)

and to investigate its influence on motilin and gastrin. Method: Ninety-six patients were randomly divided into the control group (47 cases) and the observation group (49 cases) by a random number table. Patients in the control group received 5 mg cisapride tablets thrice daily 30 min before a meal. Patients in the observation received 1 dose modified Jianpi Xiaozhi decoction in twice daily. All patients in both two groups received 4 weeks of treatment. Before and after treatment

scores of the main symptoms and signs were recorded. Gastric emptying test was conducted. Levels of motilin and gastrin were detected. Result: The total efficient rate in the observation group was 91.8%

which was superior to that of 74.4% in the control group (P<0.05). After treatment

stomach row space in the observation group was lower than that in the control group (P<0.01). Levels of plasma motilin and gastrin in the observation group were lower than those in the control group (P<0.01). Scores of fullness degree

fullness

duration

early satiety

nausea and vomiting

heating amount and defecate in the observation group were inferior to those in the control group (P<0.01). Conclusion: Modified Jianpi Xiaozhi decoction could improve clinical symptoms and promote gastric emptying in treating DGP. The clinical curative effect of therapy is better than that of cisapride. Its mechanism may be related to regulating the levels of motilin and gastrin.