Objective: To establish the chromatographic method for rapid determination of 25 pesticide residues in Ginseng extract by QuEChERS-GC-MS. Method: The samples were extracted with acetone which included acetonitrile

the sodium chloride

anhydrous magnesium sulfate salting out process

and cleaned up by PSA and GCB

and reduced the matrix effect by Matrix matched standard curve method. Result: The endrin aldehyde

p

p'-DDT

methoxychlor showed relatively strong matrix effects(ME >130%)

and parathion showed strong matrix effects (ME >150%)

after the correction of matrix calibration curve

the linear range was 0.01-1 mg·L-1 and r >0.995 4

the recovery range was 81.8%-110.7% in 3 adding level (0.1

0.5

1.0 μg·g-1)

RSD<15%

LOQ was 3-48 μg·kg-1. Conclusion: The method is accurate

sensitive and suitable for the determination of pesticide residues in ginseng extract.