Objective: To study the chemical components of the volatile oil from Wenxin granule including the main constituents and their relative content percentages among total oil. Method: The chemical components of the volatile oil from Wenxin granule were extracted and analyzed by applying Head Space Solid Phase Micro Extraction (HS-SPME) and GC-MS techniques. The chemical components were identified by retrieving NIST08.L mass spectral library (matching ≥80%)

combined with the reported literature data. Result: The 52 components were identified from the volatile oil of Wenxin granule

accounting for 67.39%. Among which

spathulenol

isocaryophyllene

caryophyllene oxide and other five compounds were the main constituents. The result was basically identical with the data reported in the literatures of the volatile oil of Nardostachyos Radix et Rhizoma. Conclusion: The research provides basis for the further material basis study of the Wenxin granule

and accumulates laboratory data for optimization of quality control.