Objective: The aim of this study was to observe the clinical efficacy of Yangxue Huaban decoction (YXHB) and its effecton serum tumor necrosis factor-α(TNF-α) and vascular endothelial growth factor(VEGF) in treating the blood dryness syndrome of plaque type psoriasis. Method: In this study

one hundred and fifteen patients with the blood dryness syndrome of plaque type psoriasis were randomly divided into the treatment group and the control group. The 78 patients in the treatment group were treated with YXHB and the 37 patients in the control group were treated with Xiaoying capsule (XY). The changes in the score of psoriasis area

severity index (PASI) and the symptoms of traditional Chinese medicine were observed before and after treatment in two groups respectively. The levels of TNF-α and VEGF in serum of psoriastic patients before and after treatment in the treatment group were detected with enzyme-linked immunosorbnent assay (ELISA)

with 30 healthy serum samples as healthy controls. The period of treatment was 8 weeks. Result: YXHB and XY apparently improved PASI score and the symptoms in TCM after treatment as compared with those before treatment (P< 0.05). The total effective rate of YXHB was 78.2%

with no significant difference compared with that of control group. YXHB relieved TCM symptoms much better than XY. Compared with healthy controls

the levels of TNF-α and VEGF with psoriastic patients were higher (P< 0.05). And comparison of TNF-α and VEGF levels before and after treatment also showed significant differences (P< 0.05). Conclusion: YXHB was effective in the treatment of the blood dryness syndrome of plaque type psoriasis. It reduced the levels of serum TNF-α and VEGF

which is partly responsible for the clinical efficacy.