Objective: To compare quality stability between compressed pieces and traditional pieces. Method: With Menthae Haplocalycis Herba

Perillae Folium

Polygoni Multiflori Caulis and Citri Reticulatae Pericarpium as research objects

long term stability test and accelerated stability test were used to study changes of quality stability between compressed pieces and traditional pieces by determining appearance

TLC

water content

volatile oil

content of pulegone

hesperidin and 2

3

5

4'-teterahydroxy stilbene-2-O-β-D-glucoside(TSG).Mobile phase of pulegone

TSG and hesperidin consisted of methanol-water (72: 28)

acetonitrile-water (18: 82)

methanol-acetic acid-water (30: 4: 66)

detection wavelengths were 252

320

283 nm

respectively. Result: After 12 months or 6 months

the content loss rates of pulegone in traditional pieces and compressed pieces were 26.62%

17.99%;TSG were 6.52% and 4.35%;hesperidin were 7.59% and 4.33%

respectively.Volatile oil from Perillae Folium and Menthae Haplocalycis Herba

the content of pulegone showed significant differences between compressed pieces and traditional pieces

but these other indexes showed no significant differences. Conclusion: Compared with traditional pieces

compressed pieces not only do not change quality of index components to ensure safety

effectiveness and stability of clinical medication

but also provide a new idea for storage of volatile constituents.