Objective: To optimize the formulation of tripterygium glycosides loaded gel paste. Method: With the overall weighted score of initial adhesion

peel strength and sensory (appearance

skin adhesive ability and residue of gel paste on the skin after peeling off) as index

the influence of contents of dihydroxyaluminum aminoacetate

glycerol

tartaric acid povidone K90 on characteristics of formulation were evaluated by undertaking experiments according to orthogonal design. Result: All the evaluated factors

especially the content of glycerol as well as dihydroxyaluminum aminoacetate

showed significant influence on characteristics of formulation. In the optimum formulation

the weight ratio of povidone K90 to dihydroxyaluminum aminoacetate

glycerol and tartaric acid was 1.50: 0.15: 30.0: 0.15.The weighted scores of initial adhesion

peel strength and sensory of the optimum formulation were 48.89

19.43 and 28.67

respectively.The prepared tripterygium glycosides loaded gel paste was uniform in size and color

exhibited good skin adhesive ability and no residue on skin after the peeling off of the gel paste. Conclusion: By using orthogonal experimental design

the formulation of glycosides loaded gel paste might be optimized effectively with reduced test times

and these factors influencing characteristics of formulation might be evaluated comprehensively.This optimized formulation is feasible and reproducible.