Objective: To observe the protective effect of Baogan granules on acute alcoholic-induced liver injury in mice. Method: The experimental mice were randomly divided into the normal group

the model group

the Hugan tablet group (0.7 g·kg·d-1)

the Like group (1.18 g·kg-1·d-1)

the high-

medium-

and low-dose Baogan granules groups (12.9

6.45

3.225 g·kg-1·d-1). The mice in the normal and model groups received an equal volume of saline. All mice received 30-day oral administration of the corresponding medicines. The acute liver injury model was induced in mice by feeding 50% alcohol at 0.012 mL·g-1 1 h later after the last administration. The serum levels of alanine aminotransferase (ALT)

aspartic transaminase (AST)

total bilirubin (TBIL)

triglyceride (TG)

high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were detected. Histopathological changes of liver tissue were observed by using the HE staining. Result: Compared with the model control group

the levels of ALT

AST

TBIL

TG and LDL increased

the level of HDL decreased in the model group (P<0.05

P<0.01). Compared with model group

the levels of ALT

AST

TBIL

TG and LDL decreased

the level of HDL increased in the high-

medium-

and low-dose Baogan granules groups (P<0.05

P<0.01). Pathological results showed that the liver cell morphology

structure

edema and inflammatory infiltration had different degrees of improvement in the Baogan granules groups. Conclusion: Baogan granules could obviously inhibit the serum levels of ALT

AST

TG and LDL; promote the HDL generation in mice. However

its effect on TBI is unclear. Moreover

it could protect the alcoholic-induced liver injury by improving liver edema and inflammatory cell infiltration.