Objective: To study the acute toxicity of different processed products of Aconiti Lateralis Radix. Method: Fifty SPF Kunming mice

half male and half female

were randomly divided into the normal group (normal saline)

the Heishunpian group

the high-temperature group

the high-pressure group and the microwave group of 10 mice each. The maximum amounts of the corresponding medicines were intragastrically administered to mice and the acute toxicity was observed. Result: Compared with the normal group

cardiac index increased in the high-pressure and microwave groups

hepatic and spleen index decreased in the high-temperature and microwave groups. There was statistical significance for the difference (P<0.05). No obvious changes for body weight and other visceral indexes were found. The pathology results showed that there was serious toxicity in heart

liver and kidney of mice. Conclusion: The maximum amount of three processed products of Aconiti Lateralis Radix was 48 g·kg-1 for mice

which was 192 times higher than the clinical dosage in humans. Three new processing products of Aconiti Lateralis Radix would be safe in clinical application.