Objective: This study aimed to investigate the impact of Tangshenning on the levels of hepatocyte growth factor (HGF)

cystatin C(CysC) and transforming growth factor-β1(TGF-β1) in patients with two deficiency of Qi and Yin and blood stasis-typed early diabetic nephropathy

to provide reference for clinical diagnosis and treatment. Method: According to random number table method

90 cases of Qi and Yin and blood stasis-typed early diabetic nephropathy patients were randomly divided into control group (n=45) and observation group (n=45). The control group was given Luodingxin treatment

on the basis of the control group

the observation group was treated with Chinese herbal medicinal Tangshenning. The curative effects

TGF-β1

urinary albumin excretion rate (UAER)

homocysteine (Hcy)

CysC

HGF

serum creatinine (SCr)

and creatinine clearance (CCr) were observed. Result: The total effective rate in observation group (93.33%) was significantly higher than control group (75.56%)

and there were significant differences (P<0.05);levels of serum UAER

Hcy

CysC after treatment in two groups were significantly lower than before treatment

with significant difference (P<0.05);serum UAER

Hcy

CysC after treatment in observation group were significantly lower than those in control group

with significant difference (P<0.05);TGF-β1 in blood and urine after treatment were significantly lower than before treatment

with significant differences (P<0.05);level of serum HGF was higher than before treatment

with significant differences (P<0.05);TGF-β1 in blood and urine and CCr after treatment in observation group were significantly lower than the control group

qith significant differences (P<0.05);level of serum HGF after treatment in observation group was significantly higher than in control group

and thedifference was significant (P<0.05). Conclusion: The effect of Tangshenning combined with western medicine on the treatment of Qi and Yin and blood stasis-typed early diabetic nephropathy patients is significantly evident

it can significantly improve HGF to protect kidney tissue

and reduce the content of CysC to improve glomerular permeability

as well as reduce the content of TGF-β1 to inhibit cell fibrosis.