Objective: To observe the effects of Ailuo Kechuanning(ALKC) on interleukin-4(IL-4)

interleukin-8(IL-8)

tumor necrosis factor alpha(TNF-α) and pulmonary function in elder chronic obstructive pulmonary disease(COPD) patients with acute exacerbation and syndrome of damp-phelgm stagnating the lung. Method: Fifty cases of elder COPD patients with acute exacerbation and syndrome of damp-phelgm stagnating the lung were selected by the muti-center

randomized

single-blind

placebo-controlled clinical trails methods.Fifty cases were randomly divided into two groups

ALKC group (n=25) and placebo-controlled group(PC group

n=25). On the base of the western drug treatment

ALKC and placebo was used in the control group. Every group was observed in terms of improvement of the symptoms

pulmonary functions

cells factors such as IL-4

IL-8

TNF-α. Result: The differences of demogra-phic

pulmonary functions

cell factors like IL-4

IL-8

TNF-α between two groups had no significant statistical differences prior to our trails. Compared with the PC group

the total effective rate in forced expiratory volume in 1 second(FEV1)

FEV1/forced vital capacity(FVC)

IL-8(0.42±0.10) μg·L-1 vs (0.48±0.12) μg·L-1

(P<0.05)

IL-4(0.28±0.09)μg·L-1 vs (0.32±0.06)μg·L-1

(P<0.05)

TNF-α(0.87±0.40)μg·L-1 vs (1.28±0.25)μg·L-1

(P<0.05)in ALKC group had significant statistical differences (P<0.05

P<0.01)

had no significant statistical differences in FVC. Conclusion: ALKC has the improvements action on clinical symptoms

pulmon-ary function and the control of inflammation in elder COPD patients with acute exacerbation and syndrome of damp-phelgm stagnating the lung.