Objective: The aim of this article was to observe the curative effect of the Dasangju mixture combined with azithromycin on mycoplasma pneumoniae (MPP) in children and investigate the bi-directional control mechanism of inflammatory response. Method: One hundred patients with MPP were randomly divided into control group and observation group with 50 patients in each group by random number table. Patients in control group took 10 mg·kg-1 azithromycin suspension on the first day as well as 5 mg·kg-1 orally daily for 4 days and stopped for 2 days

which was a course of treatment. Based on the control group

patients in observation group was added 10 mL Dasangju mixture at a time and three times a day in the children aged above 3 years old

while 5 mL at a time and three times a day in those aged younger than 3 years old. Both groups were treated for 21 days

with 7 days as a course of treatment. Then

the symptoms and signs before and after treatment were recorded and the results were evaluated by efficacy evaluation in Chinese medicine. Moreover

the serum concentrations of myeoplasma pneumoniae-immune gloulin M(MP-IgM)

interleukin-6(IL-6)

and IL-10 were determined before and after medication on the 1st day and the 21st day. Result: The duration of observation group on fever

cough and lung rale were obviously improved than the control group(P<0.05). The total effective rate in observation group was 88.00% while in the control group it was 70.00%

and there was statistical significance(P<0.05). After treatments

both the serum concentrations and the differences between before and after treatment of interleukin-6 and interleukin-10 in observation group were more significantly reduced than in the control group(P<0.05). Conclusion: Dasangju mixture combined with azithromycin can not only improve the clinical symptoms and signs

but also shorten the duration with significant effect. Meanwhile

Dasangju mixture can significantly reduce the concentrations of IL-6 and IL-10

which may be related to bi-directional control mechanism of inflammatory response.