Objective: The aim of this study was to observe the efficacy and effect of acupuncture in combination with gastrodin on the serum level of endothelin-1(ET-1) and calcitonin gene-related peptide(CGRP) in the treatment of cervical vertigo (CV) and provide clinical reference for the CV treatment. Method: One hundred and fourty cases of cervical vertigo meeting the inclusion criteria were randomly divided into two groups equally. The control group was treated with acupuncture

and the observation group was treated with acupuncture and gastrodin. Clinical effects

vertigo dizziness handicap inventory(DHI) score

transcranial Doppler (TCD) value

serum ET-1 and CGRP were observed and compared. Result: The observation group had a therapeutic efficiency ratio of 97.1%

which was statistically higher than that of 74.3% in the control group (P<0.05). After the treatment

the DHI score in the observation group was decreased more than in the control group. As to TCD value valueof left vertebral artery (LVA)

right vertebral artery (RVA) and basal artery (BA) in the observation group statistically increased more than those in the control group (all P<0.05). The serum level of ET-1 was decreased more while the level of CGRP was increased more in the observation group than in the control goup (P<0.05). Conclusion: The curative efficacy of acupuncture in combination with gastrodin in treating patients with cervical vertigo was reliable

which could significantly decrease the ET-1 level and increase the CGRP level.