Objective: To discuss the clinical efficacy of Bushen Huoxue Mingnu decoction in treating non-propagative diabetic retinopathy (NPDR) with the deficiency of liver and kidney combined collaterals stasis resistance of tradition Chinese medical (TCM) syndrome

and to investigate its influence on vascular endothelial cell growth factor (VEGF) and tumor necrosis factor-α (TNF-α). Method: Ninety-seven patients were randomly divided into the control group (47 cases) and the observation group (50 cases) by a random number table. Patients in the control group received 80 mg valsartan capsules once daily for controlling the blood glucose

40 mg simvastatin tablets once nightly

100 mg aspirin enteric-coated tablets once daily

and 0.5 g calcium dobesilate capsules thrice daily. Based on the treatment of the control group

patients in the observation added 1 dose Bushen Huoxue Mingnu decoction. All patients in both two groups received 12 weeks of treatment. Before and after treatment

vision and fundus examination were made and scores of TCM syndrome were graded. Levels of triglyceride (TG)

total cholestero l(TC)

high density lipoprotein cholesterol (HDL-C)

and low density lipoprotein cholesterol (LDL-C)

TNF-α and VEGF were detected. Result: The total effective rate of fundus lesions in the observation group was 86.3%

which was superior to that of 70.3% in the control group (P<0.05). After therapy

vision in the observation group was better than that in the control group (P<0.01). The inspection and TCM syndrome score in the observation group were lower than those in the control group (P<0.01). Levels of TG

TC and LDL-C declined after treatment in both two groups compared before (P<0.01). The LDL-C level in the observation group was lower (P<0.01)

while the HDL-C standard was higher than those in the control group (P<0.01). After treatment

TNF-α and VEGF levels in the observation group were lower than those in the control group (P<0.01). Conclusion: Based on the conventional Western treatment

Bushen Huoxue Mingmu decoction could improve vision

signs and symptoms of NPDR patients. Its clinical curative effect is superior to using Western medicine treatment alone. The mechanism may be related to regulating lipid metabolism

reducing TNF-α and VEGF levels.