Spherical crystallization is a technology to obtain spherical drugs with large particle size by controlling polymerization process of drug molecules during crystallization.As a new method of particle design

this technique can improve powder properties

including flowability

compressibility

bioavailability and so on

control process parameters and obtain spherical particles with desired particle size distribution.Process parameters during crystallization includes temperature

stirring rate

type and amount of solvents etc.This paper focuses on four classical techniques for obtaining spherical particles and give viewpoint on its industrial enlargement.