Objective: To provide theoretical and experimental basis for industrial production of Shenbo lotion by optimizing its preparation technology. Method: Volatile oil from pine needle and Schizonepetae Herba was extracted by steam distillation method

extraction technology of volatile oil was optimized through single-factor test.With comprehensive score of total alkaloids concentration and solid content as index

orthogonal design was optimized water extraction process by taking water consumption

extracting times and time as factors

concentrating and molding processes were screened by single factor test. Result: Optimum preparation process was as following:extracted 5 h with 14 times the amount of water

added 0.1% polysorbate 80 to solubilizing oil.The rest medical materials with herb residue were boiled thrice with 8 times the amount of water

1 hour for each time.Filtrate was concentrated by atmospheric pressure or reduced pressure

then adding 0.3% sodium benzoate as preservative and purifying after refrigerating 48 hours.The concentration of total alkaloids was no less than 195 mg·L-1

and its retention rate was no less than 85%. Conclusion: This preparation technology is stable and feasible

it serves as a theoretical basis for standardized production of Shenbo lotion.