Objective: To investigate the protective effects and mechanisms of Xinjiangtang granule on kidney in streptozotocin-induced type 2 diabetic mellitus (T2DM) rats. Method: Fifty male SD rats were randomly divided into the normal control group (8 rats

normal diet) and the model group (42 rats). Rats in the model group received a high-fat-diet for 4 weeks and peritoneal injection of streptozotocin (STZ

40 mg·kg-1) to induce T2DM. The T2DM rats were randomly subdivided into the model group

the metformin group (0.15 g·kg-1)

the high-and low-dose Xinjiangtang granule groups (12.64

6.32 g·kg-1). The corresoponding medicines were intragastrically administered to rats once daily for 8 weeks. After 8-week treatment

body weight

fasting blood glucose (FBG)

ureanitrogen (BUN)

serum creatinine (SCr)

total cholesterol (TC)

triglyceride(TG)

high density lipoprotein cholesterol (HDL-C)

low density lipoprotein cholesterol (LDL-C) of serum

superoxide dismutase (SOD)

malondialdehyde (MDA)

glutathione peroxidase (GSH-Px)

catalase (CAT) and transforming growth factor-β1(TGF-β1) mRNA

plasminogen activator inhibitor-1(PAI-1) mRNA of kidney were detected. Result: Compared with the normal group

the levels of FBG

BUN

SCr

TC

TG

LDL-C

MDA and mRNA expressions of PAI-1

TGF-β1 increased

the body weight

levels of HDL-C

SOD

GSH-Px and CAT decreased in the model group (P<0.05

P<0.01). Compared with model group

the levels of FBG

BUN

SCr

TC

TG

LDL-C

MDA and mRNA expressions of PAI-1

TGF-β1 decreased

the body weight

levels of HDL-C

SOD

GSH-Px and CAT increased in the Xinjiangtang granule groups (P<0.05

P<0.01). Conclusion: Xinjiangtang granule could remarkably regulate glycometabolism of T2DM rats

and mechanism may be associated with inhibiting the mRNA expressions of TGF-β1 and PAI-l

weakening oxidative stress and improving kidney function.