Objective: To explore effect of Eucommla ulmoides leaves flavonoids on blood glucose control and the protection of islet cells in diabetic rats. Method: Streptozocin was used to copy diabetic rats model

modeling rats were divided into four groups

model group

positive drug group(glyburide

10 mg·kg-1)

E.ulmoides leaves flavonoids groups (2.5

5.0 g·kg-1)

the normal group was setup. After 28 days fasting blood glucose (FBG) was collected

serum free insulin (FINS)level and oral glucose tolerance test were carried out. Superoxide dismutase (SOD)

glutathione peroxidase (GSH-Px)and malondialdehyde(MDA)content of pancreas homogenate was assayed. Hematoxylin and eosin (HE) staining was used to the microscopic observation islet morphology and cell number. Result: Compared with normal group

the significant increase of FBG and MDA

FINS falling and reduced glucose tolerance

the SOD and GSH-Px levels in model group rats were observed. Pathological islet apparently showed atrophy(P<0.01). Compared with model group

E.ulmoides leaves flavonoids could obviously decrease the MDA level

raise the level of SOD and GSH-Px

reduce FBG

improve glucose tolerance and the level of FINS(P<0.01

P<0.05). Pathological section showed that the rat islet was increased

the number of cells was increased obviously(P<0.01

P<0.05). Conclusion: E.ulmoides leaves flavonoids can obviously reduce the blood sugar of diabetic rats

improve the glucose tolerance

and increase the level of FINS

has the protection of islet cell function

antioxidative stress reaction is one of its mechanisms.