Objective: To evaluate the clinical efficacy of Tongmai Wendan decoction in patients with carotid artery atherosclerosis. Method: One hundred and twenty patients according to inclusion criteria were randomly divided into treatment group and control group

patients from treatment group receive Tongmai Wendan decoction and atorvastatin

and patients from control group was given atorvastatin

and the treatment period was 3 months

intima-media thickness of carotid arteries(IMT)

blood lipid and symptoms before and after treatment were observed. Result: After treatment

IMT and blood lipid were improved in both groups

difference of IMT between the two groups was not statistically significant

difference of total cholesterol (TC)between the two groups was statistically significant(P<0.05)

difference of low density lipoprotein cholesterol(LDL-C) between the two groups was statistically significant(P<0.05)

difference of high density lipoprotein cholesterol(HDL-C) between the two groups was statistically significant(P<0.05)

difference of trigly-ceride(TG) between the two groups was not statistically significant

some clinical symptoms such as dizziness

full feeling of the chest and sticky and greasy in mouth were improved in treatment group

the difference was statistically significant(P<0.05). Conclusion: Tongmai Wendan decoction can regulate the level of blood lipid in patients with carotid artery atherosclerosis and improve the symptoms of patients.