Objective: To discuss the clinical effect of Shuangu Sanzi capsules combined Bushen Jiangu capsules in treating osteoportic fracture

and to investigate its influence on alkaline phosphatase (ALP)

bone gla protein (BGP) and bone morphogenetic protein (BNP-2). Method: One hundred and eighteen patients were randomly divided into the control group (58 cases) and the observation group (60 cases). Patients in the control group received 0.6 g calcium carbonate D3 chewable tablet every day. For female patients during menopause

10 mg alendronate sodium tablets were added every day. Based on the treatment of the control group

patients in the observation group added 3 Shuangu Sanzi capsules and 4 Bushen Jiangu capsules thrice daily. All patients in both two groups received 6 months of treatment. Time of fracture healing and growth situation of bone callus was recorded. Before and after treatment

pain of waist and back was evaluated. The density of femur

tibia and levels of serous ALP

BGP and BMP-2 were detected. Result: The clinical effect of fracture healing in the observation group was superior to that in the control group (P<0.05). After treatment

density of the femur and tibia was higher (P<0.01)

scores of pain of the waist and back were lower in the observation group than those in the control group (P<0.01). After 2 months of treatment

score of growth situation of bone callus was higher (P<0.01)

the average time of fracture healing was lower in the observation group than those in the control group (P<0.01). Level of serous ALP was lower (P<0.01)

and levels of BGP and BMP-2 were higher in the observation group than those in the control group (P<0.01). Conclusion: Shuangu Sanzi capsules combined Bushen Jiangu capsules could promote the healing of fracture

reduce the time of fracture healing

increase bone mineral density

alleviate pain and regulate levels of ALP

BGP and BMP-2 in treating osteoportic fracture.