Objective: To discuss the clinical effect of Xiaoliu pills in treating uterus myoma of qi stagnation and blood stasis syndrome

and to explore its mechanism of action. Method: One hundred and ten patients were randomly divided into the control group (55 cases) and the observation group (55 cases) by a random number table. Patients in the control group received 25 mg mifepristone once daily. Patients in the observation group received 9 g Xiaoliu pills twice daily. All patients received 12 weeks of treatment. Before and after treatment

volume of fibroid and uterine was detected. Scores of qi stagnation and blood stasis were graded. Levels of follicle-stimulating hormone (FSH)

luteinizing hormone (LH)

prolactin (PRL)

estrogen (E2)

progesterone (P) and indexes of hemorrheology were detected. Result: The total clinical efficiency in the observation group was 94.55%

which was superior to that of 78.18% in the control group (P<0.05). After therapy

volume of fibroid and uterine in the observation group was smaller than that in the control group (P<0.01). At the eighth and twelfth week after treatment

scores of qi stagnation and blood stasis in the observation group were lower (P<0.01)

falling range was larger than those in the control group (P<0.01). After therapy

levels of whole blood viscosity (high shear

low shear)

plasmatic viscosity

fibrinogen and erythro-agglutation index decreased

and the results were lower in the control group (P<0.01). Levels of FSH

LH and E2 in observation group were lower than those in the control group (P<0.01)

while

there was no statistically significant difference for the levels of PRL and P between two groups. Conclusion: The clinical effect of Xiaoliu pills on reducing volume of fibroid and uterine and decreasing scores of qi stagnation and blood stasis was superior to mifepristone. Moreover

it could ameliorate hemorrheology and regulate female sex hormone

so it is worthy to be used in clinic.