混料均匀设计优化四制香附活性成分配伍

胡律江; 许茜茜; 赵晓娟; 胡志方; 郭慧玲; 王进诚

doi:10.13422/j.cnki.syfjx.2015140001

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混料均匀设计优化四制香附活性成分配伍

药剂与炮制 | 更新时间：2024-01-04

- 混料均匀设计优化四制香附活性成分配伍
- Compatibility of Active Ingredients in Cyperi Rhizoma by Uniform Design of Experiments with Mixtures
- 中国实验方剂学杂志 2015年21卷第14期页码：1-3
- 作者机构：
- 作者简介：
- 基金信息：
  
  江西高等学校科技落地计划项目(KJLD14057);江西省卫生厅中医药科研计划重点项目(2013Z008)
- DOI：10.13422/j.cnki.syfjx.2015140001
  中图分类号： R289.1
- 纸质出版日期：2015
- 稿件说明：
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胡律江, 许茜茜, 赵晓娟, 等. 混料均匀设计优化四制香附活性成分配伍[J]. 中国实验方剂学杂志, 2015,21(14):1-3.

HU Lyu-jiang, XU Qian-qian, ZHAO Xiao-juan, et al. Compatibility of Active Ingredients in Cyperi Rhizoma by Uniform Design of Experiments with Mixtures[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(14): 1-3.
胡律江, 许茜茜, 赵晓娟, 等. 混料均匀设计优化四制香附活性成分配伍[J]. 中国实验方剂学杂志, 2015,21(14):1-3. DOI： 10.13422/j.cnki.syfjx.2015140001.

HU Lyu-jiang, XU Qian-qian, ZHAO Xiao-juan, et al. Compatibility of Active Ingredients in Cyperi Rhizoma by Uniform Design of Experiments with Mixtures[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(14): 1-3. DOI： 10.13422/j.cnki.syfjx.2015140001.

摘要

目的: 研究四制香附主要活性成分的配伍

提高活性成分抗痛经作用的生物效应。方法: 采用混料均匀设计法拟定四制香附中3种主要活性成分香附烯酮

α-香附酮和sugeonol的配伍方案

运用Powerlab生物信号采集系统

记录小鼠离体子宫平滑肌的活动

采用平均张力变化为观察指标

探讨各活性成分与小鼠离体子宫抑制率之间的相关性

优化3种成分的配比关系。结果: 当香附烯酮-α-香附酮-sugeonol(43 :41 :16)时

样品对由缩宫素引起的小鼠离体子宫痉挛性收缩的抑制率最高。结论: 香附烯酮

α-香附酮和sugeonol之间存在明显的交互作用

配伍后的样品能显著提高抗痛经作用的生物效应

为四制香附抗痛经作用新剂型的研发及其临床应用提供实验依据。

Abstract

Objective: To study compatibility of active ingredients from Cyperi Rhizoma with Jianchangbang and examine interaction for increasing dysmenorrheal effects. Method: Compatible programs of active ingredients from Cyperi Rhizoma with Jianchangbang was developed by uniform design of experiments with mixtures.Uterine smooth muscle activity was recorded by Powerlab biological signal acquisition system in mice.Average tension changes were observed.Correlation between active ingredients and inhibition rates was explored to optimize relationship between ratios of these three components. Result: When ratio of cyperotundone

α-cyperone and sugeonol was 43: 41: 16

optimal integrated solution was obtained by establishing regression equation

contraction inhibition rate was highest by oxytocin-induced uterine spasmodic in mice. Conclusion: Cyperotundone

α-cyperone and sugeonol has significant interaction

dysmenorrheal effects of samples are increased significantly after compatibility of three components.

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