Box-Behnken响应面法优化牡丹皮炭炮制工艺

朱琼花; 莫毛燕; 孟江; 周苏娟; 王淑美; 梁生旺

doi:10.13422/j.cnki.syfjx.2015140012

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Box-Behnken响应面法优化牡丹皮炭炮制工艺

药剂与炮制 | 更新时间：2024-01-04

- Box-Behnken响应面法优化牡丹皮炭炮制工艺
- Optimization of Processing Technology for Moutan Cortex Carbon by Box-Behnken Response Surface Methodology
- 中国实验方剂学杂志 2015年21卷第14期页码：12-15
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(81473352);国家中医药管理局中医药行业科研专项(201207004-7)
- DOI：10.13422/j.cnki.syfjx.2015140012
  中图分类号： R283
- 纸质出版日期：2015
- 稿件说明：
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朱琼花, 莫毛燕, 孟江, 等. Box-Behnken响应面法优化牡丹皮炭炮制工艺[J]. 中国实验方剂学杂志, 2015,21(14):12-15.

ZHU Qiong-hua, MO Mao-yan, MENG Jiang, et al. Optimization of Processing Technology for Moutan Cortex Carbon by Box-Behnken Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(14): 12-15.
朱琼花, 莫毛燕, 孟江, 等. Box-Behnken响应面法优化牡丹皮炭炮制工艺[J]. 中国实验方剂学杂志, 2015,21(14):12-15. DOI： 10.13422/j.cnki.syfjx.2015140012.

ZHU Qiong-hua, MO Mao-yan, MENG Jiang, et al. Optimization of Processing Technology for Moutan Cortex Carbon by Box-Behnken Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2015, 21(14): 12-15. DOI： 10.13422/j.cnki.syfjx.2015140012.

摘要

目的: 优选牡丹皮炭的炮制工艺。方法: 采用砂烫法

以5-羟甲基糠醛、没食子酸、儿茶素、丹皮酚含量的综合评分为指标

在单因素试验基础上

选择炮制时间、炮制温度、投料比为自变量

采用Box-Behnken响应面法优化牡丹皮炭的炮制工艺。结果: 牡丹皮炭最佳炮制工艺为炮制时间9.0 min

炮制温度180.0 ℃

投料比25.5倍。5-羟甲基糠醛、没食子酸、儿茶素、丹皮酚质量分数分别为0.022 1%

0.023 3%

0.175 7%

0.042 0%

综合评分预测值97.67分

实测值95.01分。结论: 优选的炮制工艺简便可行

预测性良好

充分体现了牡丹皮炭凉血止血、止血而不留瘀的作用特点。

Abstract

Objective: To optimize processing technology of Moutan Cortex carbon. Method: With the content of gallic acid

5-hydroxymethyl furfural

catechin

paeonol as comprehensive evaluation index

based on single factor tests

herb-to-sand ratio

processing time and temperature were selected as independent variables

sand-scorch method was adopted

processing technology of Moutan Cortex carbon was optimized by Box-Behnken response surface methodology. Result: Optimum processing conditions were as follows:processing time of 9.0 min

processing temperature at 180.0 ℃

herb-to-sand ratio of 25.5: 1.The content of 5-hydroxymethyl furfural

gallic acid

catechin and paeonol were 0.022 1%

0.023 3%

0.175 7% and 0.042 0%

respectively.The measured value of composite score was 95.01

which was close to the predicted value of 97.67. Conclusion: This optimized processing technology of Moutan Cortex carbon is simple and feasible with good predictability

which fully embodies function characteristics of this herb.

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