Objective: To optimize extraction and purification procedure of Chuanxiong Rhizoma in compound Shenxiong dropping pills. Method: Ethonal extraction of Chuanxiong Rhizoma was conducted through orthogonal design with contents of ferulic acid and ligustilide as indexes

solvent extraction method was used to purify Chuanxiong Rhizoma extract on the basis of single factor experiments

effects of different concentration

solvent volume and extraction times were studied.Contents of ferulic acid and ligustilide were determine by HPLC

methanol-0.05% phosphoric acid as mobile phase in a gradient elution

detection wavelength was 320 nm. Result: Optimum extraction procedure was that medicinal materials were extracted 2 times with 10 times the amount of 70% ethanol

2 hours for each time.Contents of ferulic acid and ligustilide in extract were 1.46

13.84 mg · g-1.Diversion rate of ferulic acid and ligustilide were 94.68% and 85.86%.Purification procedure was carried out by extracted 3 times with 2 times the amount of ethyl acetate for each time. Conclusion: Extraction rate of active components is high by optimized extraction and purification procedure

which can provide experimental basis for industrial production of compound Shenxiong dropping pills.