Objective: To observe the effects of the different Mori Folium extracts on lipid metabolism in sodium hydrogen glutamate (MSG) obese rats. Method: Subcutaneous injection of 4 g · kg-1 · d-1 L-glutamate in new born SD rats for seven days was used to establish the MSG obese rat model

the modeling rats were randomly divided into model group

rosiglitazone group(5 mg · kg-1 · d-1)

fenofibrate group(100 mg · kg-1 · d-1)

Mori Folium polysaccharide groups at dose of 625

312.5 mg · kg-1 · d-1

Mori Folium flavonoids groups at dose of 80

40 mg · kg-1 · d-1

and Mori Folium alkaloid groups at dose of 5 000

2 500 mg · kg-1 · d-1. Another 8 normal rats were as the normal group. The levels of lipid in serum and liver and the level of nonestesterified fatty acid(NEFA) in serum were measured after administration for 8 weeks. Real-time PCR was used to detect the expression level of peroxisome proliferator-activated receptor α(PPARα)

carnitine palmitoyl transferaseⅠ (CPTⅠ) and acyl-CoA oxidase 1(ACOX1). Result: Compared with the normal group

the model group increased the level of lipid in serum

liver and skeletal muscle significantly (P<0.01)

and inhibited the expression of PPARα

CPTⅠ and ACOX1 (P<0.01

P<0.05). Compared with the model group

each of treatment groups has some improvements in the level of lipid in serum

liver and skeletal muscle and the level of NEFA in serum and the level of genes expression. Conclusion: Mori Folium can improve the lipid metabolism in MSG rats by activating the PPARα receptor and regulating the process of fatty acid oxidation.