Objective: To observe clinical effect of Yigan San in treating attention deficit hyperactivity disorder(ADHD) combined with hyperactivity syndrome. Method: Ninety-four patients with ADHD were randomly divided into control group (47 cases) and observation group(47 cases) by random number table. Both group received methylphenidate hydrochloride tablets for a continued 12 weeks

5 mg/time

2 times/day. Patients in control group received Jingling oral liquid

10 mL/time

2 times/day

patients in observation group received of Yigan San

1 dose/day. Treatment courses were continuing for 12 weeks. Before and after treatment

score the Swanson

Nolan

and Pelham

Version IV(SNAP-IV) scale (parent version)

Conner behavior assessment scale

Wechsler intelligence and syndrome of hyperactivity of Yang due to Yin deficiency. Result: By Ridit analysis

clinical curative effect in observation group was superior to that in control group(P<0.05).The SNAP-Ⅳ scale and syndrome of hyperactivity of Yang due to Yin deficiency scores in observation group were less than those in control group(P<0.01). Factor scores as Conner scale learning

moral

physical and mental disabilities

impulse and hyperactivity

anxiety and more dynamic index in observation group were lower than those in control group(P<0.01). Wechsler intelligence such as Verbal comprehension index (VCI)

index (PRI) perception reasoning

working memory (WMI)

processing speed index (PSI)

general ability index (GAI)

cognitive skill index (CPI)

the general intelligence (FSIQ) scores in observation group were better than those in control group(P<0.01). Conclusion: Yigan San can reduce each factor score as syndrome of hyperactivity of Yang due to Yin deficiency

SNAP-IV rating scale and Conner behavior assessment scale with ADHD children

enhance Wechsler intelligence each factor scores. It can promote ADHD symptoms and patient's level of intelligence.The clinical curative effect was better than the Jingyouling oral liquid.