Objective: Discuss protection effect of Niaoduqing particles combined conventional western medicine therapy treat gouty nephropathy renal function. Method: Ninety-nine patients were randomly divided into control group(49 cases) and observation group(50 cases). Patients in control group took allopurinol tablets on the basis of adjusting the diet habit

100 mg/time

2 does/day. Sodium bicarbonate tablets

1 g/time

3 does/day. Based on the therapy in control group

patients in observation group added Niaoduqing particles

5 g/time

3 does/day

taken with boiled water. Treatment courses in two groups were both 12 weeks. Observe indicators changes as 24 h urine protein quantitative (Upro)

urine routine

creatinine (Cr)

blood urea nitrogen (BUN)

uric acid (UA)

urinary inhibition-C(Cys-C)

β2-microglobulin (β2-MG)

urinary n-acetyl-β-amino glycosidase enzymes (NAG) and xanthine oxidase (XOD) before and after treatment. Score the lienal kidney deficient empty and wet muddy resistance card symptoms before and after therapy. Result: By Ridit analysis

the disease curative effect and traditional Chinese medicine syndrome curative effect in observation group were superior to those in control group(P<0.05). Levels of Upro

Cr

BUN and UA in observation group were inferior to the standards in control group(P<0.05

P<0.01). XOD

Cys-C

β2-MG and NAG in observation group were less than those in control group(P<0.05

P<0.01). Conclusion: Based on lifestyle intervention and conventional western medicine treatment

Niaoduqing particles can reduce Upro

Cr

BUN

UA

XOD

Cys-C

β2-MG and NAG levels with gouty nephropathy disease. It has certain protective effect for renal function. Its disease curative effect and traditional Chinese medicine syndrome curative effect are superior to using western medicine therapy alone.