Objective: The aim of this study was to siscuss the influence of Tangmaikang particles on glucose fluctuation and impact on oxidative stress

and the function of vascular endothelium in treating type-two diabetes mellitus (T2DM). Method: Two hundred and thirty patients with T2DM were randomly divided into control group and observation group by random number table.Patients in control group received repaglinide tablets.Based on the treatment of control group

patients in observation group were added Tangmaikang particles.Before and after treatment

continuous glucoses including standard deviation of blood glucose level (SDBG)

mean amplitude of glycemic excursions (MAGE)

mean of daily differences (MODD)

and mean postprandial glucose excursion (MPPGE)were monitored;and fasting blood-glucose (FBG)

fasting insulin(FINS)

two hours' postprandial blood glucose (2 hPBG) and glycosylated hemoglobin (HbA1c)were detected

and indexes of homeostasis model assessment of insulin resistance (HOMA-IR)

secretion function of pancreas islet B cell and insulin sensitivity(ISI) were calculated.The serum triglyceride (TG)

total cholesterol (TC)

high density lipoprotein (HDL-C)

and low density lipoprotein (LDL-C) were measured. Result: After treatment

indexes of SDBG

MAGE

MODD

MPPGE

HOMA-IR FBG

2 hPBG

HbA1c

TG

TC and LDL-C in observation group were all lower than those in control group

but the indexes of HOMA-IS and ISl were higher than those in control group (P<0.05). Conclusion: Tangmaikang particles can reduce blood glucose of patients with T2DM

keep the stability of blood glucose

regulate the intraday glucose fluctuation

and improve blood lipid metabolism

which is worthy of clinical application.