Objective: The aim of this study was to evaluate the effectiveness and safety of Cinobufacini injection on esophageal cancer. Method: We searched the Cochrane Central Register of Controlled Trials (CCTR)

PubMed

CBM

CNKI

VIP databases before Dec. 2013.The methodological quality assessment and data extraction of the included studies were conducted by two reviewers independently according to the inclusion and exclusion criteria. Meta-analyses were performed for homogeneous studies using RevMan 4.2.10 software. Result: A total of 7 studies involving 566 patients met the inclusion criteria. None of the studies enforced allocation concealment and performed blinding. Conclusion: On the basis of radiotherapy and chemotherapy

dripping Cinobufacini injection can improve the clinical curative effect

which had advantage than radiotherapy and chemotherapy alone;based on radiation

dripping Cinobufacini injection can improve the one-year and two-year survival rate

which had advantage than radiotherapy alone;based on chemotherapy

dripping Cinobufacini injection can improve the life quality of patients

which was better than chemotherapy alone. What's more

the one-year survival rate has been increased

and the improvement of leukopenia decrease caused by chemotherapy also presented a better trend. However

because the overall effects cannot be pooled for analysis

more evidence is needed to support this conclusion.