Objective: To system atically review the effective ness and safety of Yanhuning for curing the hand-foot-mouth disease (HFMD). Method: Methods included a structured search strategy on The Cochrane Library

EBSCO

EMbase

PubMed

CBM

VIP

CNKI and Wanfang Data data bases;randomized controlled trial (RCT) of HFMD relevant Yanhuning treatment of search

were searched from inception to 2014 October;according to the inclusion and exclusion criteria in dependent screening literature

data extraction and quality assessment

Meta-analysis was carried out using Rev Man 5.3 software. Result: 51 RCT were included

7 718 cases. Results showed that:Yanhuning or Yanhuning combined Ribavirin group's efficiency in patients with fever

total time

ulcers resolve time have more advantages than single Ribavirin

with statistical difference. In the aspec to fsafety

Yanhuning injection group

the incidence rate of adversea ction was 2.48%

slightly lower than the Ribavirin group 2.57%. Conclusion: Yanhuning injection in the treatment of HFMD has good curative effect and low incidence rate of adverse action.But because of the overall poor quality into literature

RCT is needed to design multi center

large sample of more rigorous further confirmed the conclusion.