Objective: To study the anti-myocardial ischemia effect of Danshen oral solution. Method: Totally 70 SD rats were randomly divided into seven groups

with 10 rats in each group. Specifically

they were the control group

the model control group

the Aspirin group (50 mg · kg-1)

the compound Danshen dripping pills group (135 mg · kg-1)

the Danshen tablets group (300 mg · kg-1)

Danshen oral solution high and low dose groups (5

2.5 g · kg-1). They were orally administered with corresponding drugs for 7 days. One hour later after the last administration

the normal group was injected with physiological saline (5 mL · kg-1) through femoral veins

while the other groups were included into the blood stasis model by being injected with 10% high molecular dextran (5 mL · kg-1). Another 70 rats were randomly divided into seven groups

with 10 rats in each group. Specifically

they were the control group

the model control group

the Isosorbide mononitrate group (4 mg · kg-1)

the compound Danshen dripping pills group (135 mg · kg-1)

the Danshen tablets group (300 mg · kg-1)

Danshen oral solution high and low dose groups (5

2.5 g · kg-1). They were orally administered with corresponding drugs for 7 days. One hour later after the last administration

the normal control group was sublingually injected with normal saline

while the other groups were included into the myocardial ischemia model rats by being sublingually injected with pituitrin 0.5 U · kg-1 (1 U · mL-1). The blood and plasma viscosities of rats in the blood stasis model were detected by blood viscometer. The changes of T wave in electrocardiogram(ECG) at different time points of rats in the blood stasis model were recorded

and creatine kinase (CK) and malonyldialdehyde (MDA) in plasma

superoxide dismutase (SOD)

Ca2+ and MDA in plasma were determined. Result: Compared with the normal group

the blood and plasma viscosities of the model group increased significantly (P<0.01)

T wave at different time points in model rats increased significantly (P<0.05

P<0.01)

heart rate

MDA and CK in plasma of model rats increased significantly (P<0.01)

MDA and Ca2+content in myocardial tissues of model rats increased significantly (P<0.01)

SOD in myocardial tissues of model rats decreased significantly (P<0.05). Compared with the model group

Danshen oral solution high and low dose groups significantly reduce the blood and plasma viscosities in blood stasis rats (P<0.05

P<0.01) and T wave and heart rate in myocardial ischemia rats (P<0.01)

MDA

CK in plasma (P<0.05

P<0.01) and MDA and Ca2+ content in myocardial tissues of rats (P<0.05

P<0.01) and significantly increase SOD (P<0.05). Conclusion: Danshen oral solution has the protective effect in promoting circulation and removing blood stasis among blood stasis model rats and myocardial ischemia rats.