Objective: To investigate the effect of Yulin decoction on the secretion function of granulosa cells in cytoxan-induced (CTX) ovarian reserve declined rats. Method: The rats were randomly divided into 6 groups:the normal group (distilled water

20 mL · kg-1)

the model group (distilled water

20 mL · kg-1)

the progynova group (0.21 mg · kg-1)

the high-

medium-and low-dose Yulin decoction groups (15.2

30.4

60.8 g · kg-1) of 10 rats each. The ovarian reserve declined rats model were induced by injecting CTX intraperitoneally. The corresponding medicines were intragastrically administered rats for 21 days. Histomorphology changes of ovaries

the numbers of follicle and corpus luteum were observed

serum levels of follicle stimulating hormone (FSH)

luteinizing hormone (LH)

anti-mullerian hormone (AMH) were determined by radioimmunoassay. Result: Compared with the normal group

the levels of FSH and LH increased

AMH level decreased

the numbers of follicle and corpus luteum decreased in the model group (P<0.05). Compared with the model group

the levels of FSH and LH decreased in Yulin decoction groups

AMH level increased in the medium-dose Yulin decoction and progynova groups

the numbers of follicle and corpus luteum increased in the medium-and high-dose Yulin decoction groups (P<0.05). Conclusion: Yulin decoction could improve the ovarian reserve function by regulating the secretion function of granulosa cells of ovarian reserve declined rats.