Objective: To observe the clinical therapeutic effect of Yangxue Sanhan granule in treating the diabetic peripheral neuropathy (Qi and blood deficiency

cold-dampness syndrome). Method: Totally sixty patients with diabetic peripheral neuropathy were randomly divided into the treatment group and the control group and treated for the basic hypoglycemia. The treatment group was administered with Yangxue Sanhann granules

while the control group was given mecobalamine tablets. The study lasted for 12 weeks. The traditional Chinese medicine(TCM) symptom score and nerve conduction velocity of both groups were detected during and after the study. Result: The total effective rate of the treatment group was 72.41%

and that of the control group was 14.29%

with statistical differences (P<0.05). Both groups showed lower TCM symptom scores compared with their own scores before and after the treatment (P<0.01) and statistical differences in TCM symptom scores after the treatment (P<0.01)

without intra-group and inter-grioup significant difference in the nerve conduction velocity. Conclusion: Yangxue Sanhan granules can treat the diabetic peripheral neuropathy (Qi and blood deficiency

cold-dampness syndrome)

effectively improve the clinical symptoms

particularly such symptoms as pain and fatigue

with a better comprehensive clinical efficacy than mecobalamine tablets. However

both groups showed no notable improvement in the nerve conduction velocity.