Objective: To discuss the effect of Shenqi Jiangtang capsule in regulating sugar and lipid metabolism of patients with type 2 diabetes combined with dyslipidemia and on the levels of serum tumor necrosis factor-α (TNF-α)

adiponectin (APN)

leptin (LP)

hypersensitive c-reactive protein (hs-CRP). Method: Totally 106 patients were randomly divided into the observation group (54 cases) and the control group (52 cases). Both groups were given Metformin Hydrochloride tablets and Acarbose Tablets to control blood sugar. The control group took Atorvastatin tablets (20 mg · d-1

taking before sleeping).The observation group took Shenqi Jiangtang capsule (3 pieces/time

tid). Both groups were treated for 12 weeks. Before and after the treatment

the levels of fasting blood glucose (FBG)

2 hours postprandial blood glucose (PBG) and glycosylated hemoglobin (HbAlc) were detected. The insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI)

total cholesterol (TC)

triglyceride (TG)

low density lipoprotein cholesterol (LDL-C)

high density lipoprotein cholesterol (HDL-C)

apolipoprotein A (ApoA)

apolipoprotein B (ApoB)

TNF-α

APN

LP

hs-CRP were calculated. A safety evaluation was conducted. Result: According to the Ridit analysis

there was no significantly statistical difference in the blood lipid efficacy between the observation group and the treatment group. After the treatment

the levels of HbA1c

HOMA-IR in the observation group were lower than that in the control group

with higher ISI than that in the control group (P<0.05). The levels of TC

TG

LDL-C and ApoB in both groups declined but HDL-C and ApoA levels increased compared with that before the treatment (P<0.01). The LDL-C level in the observation group was higher than that in the control group (P<0.05)

with no statistical difference in other indexes in the inter-group comparison. And the observation group showed lower TNF-α

LP

hs-CRP levels but higher APN than that in the control group (P<0.05). Conclusion: Shenqi Jiangtang capsule has a certain effect in regulating sugar and lipid metabolism and inflammatory factors of patients with diabetes combined with dyslipidemia and improving HOMA-IR

with few side effects.